DNA double-strand breaks and individual factors in CT scanning

Publication

[PUBLICATIONS] Role of ATM-dependent DNA double-strand break distribution and signaling after cancer cell exposure

Objective

Given the increase in doses delivered over the years, and in view of the questions raised by certain epidemiological studies concerning an increased risk of radiation-induced cancer in CT scanners, understanding the effects of these low radiation doses has become an important social issue. What’s more, it now appears that individual factors can significantly influence the clinical and biological response to radiation.

Patients and Methods

In order to study differences in recognition and repair of radiation-induced DNA double-strand breaks, we exposed 20 primary cell lines of fibroblasts, astrocytes and mammary epithelial cells to the exact conditions of standard CT scans (brain or thorax) using customized phantoms.

Results

The results show considerable inter-individual and intra-individual variability in double-strand break signaling and recognition, depending on the tissue analyzed.

Conclusion

The individual factor must be taken into account when assessing radiodiagnostic risk. This study is innovative in terms of the tissue-specific cellular exposure models, the biological markers studied and the monitoring of absorbed dose.

[PUBLICATIONS] Role of ATM-dependent DNA double-strand break distribution and signaling after cancer cell exposure

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